English Name: Sunitinib Malate Capsules
Chinese Pinyin: Pingguosuan Shunitini Jiaonang
The main ingredient of this product is sunitinib malate.
Chemical Name: (Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1,2-dihydro-3H-indole-3-ylidene)methyl]-2,4-dimethyl-3-carbamoyl-1H-pyrrole malate
| 【Name】 | Common Name: Sunitinib Malate Capsules English Name: Sunitinib Malate Capsules Chinese Pinyin: Pingguosuan Shunitini Jiaonang |
|---|---|
| 【Ingredients】 | Main Ingredient: sunitinib malate Chemical Name: (Z)-N-[2-(diethylamino)ethyl]-5-[(5-fluoro-2-oxo-1,2-dihydro-3H-indole-3-ylidene)methyl]-2,4-dimethyl-3-carbamoyl-1H-pyrrole malate Structural Formula:
Molecular Formula: C22H27FN4O2·C4H6O5 Molecular Weight: 532.56 Excipients: mannitol, polyvinylpyrrolidone, crosslinked sodium carboxymethyl cellulose, and magnesium stearate |
| 【Description】 | This product is a capsule with the content of yellow to orange granules. |
| 【Indication】 | 1) Inoperable advanced renal cell carcinoma (RCC) 2) Imatinib mesylate failed or intolerable gastrointestinal stromal tumor (GIST) 3) Unresectable, metastatic well-differentiated advanced pancreatic neuroendocrine tumor (PNET) in adult patients. |
| 【Strength】 | 12.5mg (as sunitinib) |
| 【Dosage and Administration】 | The recommended dose of sunitinib in the treatment of gastrointestinal stromal tumor and advanced renal cell carcinoma is 50mg orally once daily for 4 weeks with a 2-week discontinuation period (4/2 dosing regimen). For pancreatic neuroendocrine tumor, the recommended dose of sunitinib is 37.5mg orally once daily with no discontinuation period. It can be taken with or without food. Note: Please refer to the Product Manual for details. |
